Macrosphelide A Exhibits a Specific Anti-Cancer Effect by Simultaneously Inactivating ENO1, ALDOA, and FH

• Main Authors: Kyoung Song (Author), Nirmal Rajasekaran (Author), Chaithanya Chelakkot (Author), Hun Seok Lee (Author), Seung-Mann Paek (Author), Hobin Yang (Author), Lina Jia (Author), Hee Geon Park (Author), Woo Sung Son (Author), Yu-Jin Kim (Author), Joon-Seok Choi (Author), Hae Min Jeong (Author), Young-Ger Suh (Author), Hwayoung Yun (Author), Young Kee Shin (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aerobic glycolysis in cancer cells, also known as the Warburg effect, is an indispensable hallmark of cancer. This metabolic adaptation of cancer cells makes them remarkably different from normal cells; thus, inhibiting aerobic glycolysis is an attractive strategy to specifically target tumor cells...