Formulation of Solid Lipid Nanoparticles Loaded with Nociceptin/Orphanin FQ (N/OFQ) and Characterization in a Murine Model of Airway Hyperresponsiveness

• Main Authors: Davida Mirra (Author), Giuseppe Spaziano (Author), Renata Esposito (Author), Debora Santonocito (Author), Rosanna Filosa (Author), Fiorentina Roviezzo (Author), Gaetano Malgieri (Author), Gianluca D'Abrosca (Author), Pasquale Iovino (Author), Luca Gallelli (Author), Roberto Fattorusso (Author), Carmelo Puglia (Author), Bruno D'Agostino (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Asthma is characterized by chronic inflammation and a variable degree of airway hyperresponsiveness (AHR). Our previous papers documented a role for Nociceptin/Orphanin FQ (N/OFQ) and its receptor N/OFQ peptide (NOP) in AHR. Therefore, the aim of this study was to improve the bioavailability of N/OF...