A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors

• Main Authors: Rajaa El Meskini (Author), Anthony J. Iacovelli (Author), Alan Kulaga (Author), Michelle Gumprecht (Author), Philip L. Martin (Author), Maureen Baran (Author), Deborah B. Householder (Author), Terry Van Dyke (Author), Zoë Weaver Ohler (Author)
• Format: Book
• Published: The Company of Biologists, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Previous work describes a genetically engineered mou...