Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches.

• Main Authors: Lilian Hernández Alvarez (Author), Dany Naranjo Feliciano (Author), Jorge Enrique Hernández González (Author), R O Soares (Author), Diego Enry Barreto Gomes (Author), Pedro Geraldo Pascutti (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Fasciola hepatica is the causative agent of fascioliasis, a disease affecting grazing animals, causing economic losses in global agriculture and currently being an important human zoonosis. Overuse of chemotherapeutics against fascioliasis has increased the populations of drug resistant p...