Metformin suppresses epithelial sodium channel hyperactivation and its associated phenotypes in a mouse model of obstructive lung diseases

• Main Authors: Ryunosuke Nakashima (Author), Hirofumi Nohara (Author), Noriki Takahashi (Author), Aoi Nasu (Author), Megumi Hayashi (Author), Tomoki Kishimoto (Author), Shunsuke Kamei (Author), Haruka Fujikawa (Author), Kasumi Maruta (Author), Taisei Kawakami (Author), Yuka Eto (Author), Keiko Ueno-Shuto (Author), Mary Ann Suico (Author), Hirofumi Kai (Author), Tsuyoshi Shuto (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the world, and has no radical treatment. Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic target against COPD. One possible modulator of ENaC...