Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

• Main Authors: Anne L. Robertson (Author), Nikolay V. Ogryzko (Author), Katherine M. Henry (Author), Catherine A. Loynes (Author), Matthew J. Foulkes (Author), Marco M. Meloni (Author), Xingang Wang (Author), Christopher Ford (Author), Malcolm Jackson (Author), Philip W. Ingham (Author), Heather L. Wilson (Author), Stuart N. Farrow (Author), Roberto Solari (Author), Roderick J. Flower (Author), Simon Jones (Author), Moira K. B. Whyte (Author), Stephen A. Renshaw (Author)
• Format: Book
• Published: The Company of Biologists, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is...