Controlled isoflurane anesthesia exposure is required for reliable behavioral testing in murine surgical models

• Main Authors: Kensuke Toyama (Author), Joshua M. Spin (Author), Yasunori Abe (Author), Yasuyuki Suzuki (Author), Alicia C. Deng (Author), Markus U. Wagenhäuser (Author), Takuya Yoshino (Author), Joscha Mulorz (Author), Shuang Liu (Author), Philip S. Tsao (Author), Masaki Mogi (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effects of variations in anesthesia exposure time prior to conducting anxiety response behavioral testing in sham controls from an experimental murine model. The staying time in the center area of the Open Field test in the "long exposure" group was significantly decrea...