Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

• Hauptverfasser: Zeenath Unnisa (Verfasst von), Kameshwar P. Singh (Verfasst von), Ellen C. Henry (Verfasst von), Catherine L. Donegan (Verfasst von), John A. Bennett (Verfasst von), Thomas A. Gasiewicz (Verfasst von)
• Format: Buch
• Veröffentlicht: Hindawi Limited, 2016-01-01T00:00:00Z.
• Schlagworte: article
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The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor belonging to the Per-Arnt-Sim (PAS) family of proteins. The AHR is involved in hematopoietic stem cell (HSC) functions including self-renewal, proliferation, quiescence, and differentiation. We hypothesize that AHR impact...