Pulmonary Delivery of Favipiravir in Rats Reaches High Local Concentrations without Causing Oxidative Lung Injury or Systemic Side Effects

• Main Authors: Ozlem Akbal-Dagistan (Author), Mustafa Sevim (Author), Leyla Semiha Sen (Author), Nur Sena Basarir (Author), Meltem Culha (Author), Aybige Erturk (Author), Hanan Fael (Author), Engin Kaptan (Author), Serap Sancar (Author), Lutfiye Mulazimoglu Durmusoglu (Author), Berrak C. Yegen (Author), Ayca Yildiz-Pekoz (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Favipiravir displays a rapid viral clearance, a high recovery rate and broad therapeutic safety; however, its oral administration was associated with systemic side effects in susceptible patients. Considering that the pulmonary route could provide a high drug concentration, and a safer application w...