Concomitant inhibition of PI3K/mTOR signaling pathways boosts antiproliferative effects of lanreotide in bronchopulmonary neuroendocrine tumor cells

• Main Authors: Claus von Hessert-Vaudoncourt (Author), Sara Lelek (Author), Christina Geisler (Author), Teresa Hartung (Author), Vanessa Bröker (Author), Franziska Briest (Author), Liliana Mochmann (Author), Fabian Jost-Brinkmann (Author), Dagmar Sedding (Author), Joana Benecke (Author), Helma Freitag (Author), Sebastian Wolfshöfer (Author), Hedwig Lammert (Author), Svenja Nölting (Author), Michael Hummel (Author), Jörg Schrader (Author), Patricia Grabowski (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Somatostatin analogues (SSAs) are commonly used in the treatment of hormone hypersecretion in neuroendocrine tumors (NETs), however the extent to which they inhibit proliferation is much discussed.Objective: We studied the antiproliferative effects of novel SSA lanreotide in bronchopul...