Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer

• Ngā kaituhi matua: Ruchita Selot (Author), Sathyathithan Arumugam (Author), Bertin Mary (Author), Sabna Cheemadan (Author), Giridhara R. Jayandharan (Author)
• Hōputu: Pukapuka
• I whakaputaina: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Of the 12 common serotypes used for gene delivery applications, Adeno-associated virus (AAV)rh.10 serotype has shown sustained hepatic transduction and has the lowest seropositivity in humans. We have evaluated if further modifications to AAVrh.10 at its phosphodegron like regions or predicted immun...