Rotenone Protects Against Acetaminophen-Induced Kidney Injury by Attenuating Oxidative Stress and Inflammation

• Main Authors: Hu Hua (Author), Xuhua Ge (Author), Mengqiu Wu (Author), Chunhua Zhu (Author), Lihong Chen (Author), Guangrui Yang (Author), Yue Zhang (Author), Songming Huang (Author), Aihua Zhang (Author), Zhanjun Jia (Author)
• Format: Book
• Published: Karger Publishers, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: In clinic, excessive acetaminophen (APAP) can cause kidney damage with uncertain mechanisms. Recently, accumulating evidence demonstrated a pathogenic role of mitochondrial dysfunction in the kidney injury. Thus, in this study, rotenone, a mitochondrial complex I inhibitor, was appl...