Benzylidene Barbituric Acid Derivatives Shown Anticonvulsant Activity on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide Pathway

• Main Authors: Shabnam Mahernia (Author), Niusha Sharifi (Author), Malihe Hassanzadeh (Author), Nastaran Rahimi (Author), Nastaran Pourshadi (Author), Arash Amanlou (Author), Ahmad Reza Dehpour (Author), Massoud Amanlou (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACT Background: Barbituric acid derivatives have long been used as central nervous system (CNS) suppressants, such as sedatives, hypnotics and anticonvulsants. In addition, previous studies have implicated the involvement of nitric oxide (NO) in the anticonvulsive effects of barbiturates in CNS...