Suppressing circ_0008494 inhibits HSCs activation by regulating the miR-185-3p/Col1a1 axis

• Main Authors: Binbin Li (Author), Jiaming Zhou (Author), Yuanyuan Luo (Author), Kegong Tao (Author), Lifen Zhang (Author), Ying Zhao (Author), Yong Lin (Author), Xin Zeng (Author), Hongyu Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Hepatic fibrosis (HF) is characterized by activation of hepatic stellate cells (HSCs) and extensive deposition of extracellular matrix components, especially collagens. However, effective antifibrotic therapies are still lacking. Recently, circular RNAs (circRNAs) have been identified as...