Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer

• Main Authors: Esther Moreno (Author), Juan M. Rosa-Rosa (Author), Tamara Caniego-Casas (Author), Ignacio Ruz-Caracuel (Author), Cristian Perna (Author), Carmen Guillén (Author), José Palacios (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with intact expression of MLH1 and MSH2. Case presentation We review the frequ...