Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer

• मुख्य लेखकों: Esther Moreno (लेखक), Juan M. Rosa-Rosa (लेखक), Tamara Caniego-Casas (लेखक), Ignacio Ruz-Caracuel (लेखक), Cristian Perna (लेखक), Carmen Guillén (लेखक), José Palacios (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Immunohistochemistry (IHQ) is commonly used for the detection of mismatch repair proteins deficiency (MMRD). One very infrequent abnormal pattern of MMR protein expression is the loss of PMS2 and MSH6, with intact expression of MLH1 and MSH2. Case presentation We review the frequ...