Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

• Main Authors: Mario Ost (Author), Verena Coleman (Author), Anja Voigt (Author), Evert M. van Schothorst (Author), Susanne Keipert (Author), Inge van der Stelt (Author), Sebastian Ringel (Author), Antonia Graja (Author), Thomas Ambrosi (Author), Anna P. Kipp (Author), Martin Jastroch (Author), Tim J. Schulz (Author), Jaap Keijer (Author), Susanne Klaus (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Fibroblast growth factor 21 (FGF21) was recently discovered as stress-induced myokine during mitochondrial disease and proposed as key metabolic mediator of the integrated stress response (ISR) presumably causing systemic metabolic improvements. Curiously, the precise cell-non-autonomous...