Anticancer activity and toxicity of new quaternary ammonium geldanamycin derivative salts and their mixtures with potentiators

• Asıl Yazarlar: Natalia Skrzypczak (Yazar), Krystian Pyta (Yazar), Piotr Ruszkowski (Yazar), Przemysław Mikołajczak (Yazar), Małgorzata Kucińska (Yazar), Marek Murias (Yazar), Maria Gdaniec (Yazar), Franz Bartl (Yazar), Piotr Przybylski (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Geldanamycin (GDM) has been modified by different type neutral/acidic/basic substituents (1-7) and by quinuclidine motif (8), transformed into ammonium salts (9-13) at C(17). These compounds have been characterised by spectroscopic and x-ray methods. Derivative 8 shows better potency than GDM in MCF...