Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype.

• Main Authors: Stefan W Metz (Author), Ashlie Thomas (Author), Alex Brackbill (Author), Yi Xianwen (Author), Michele Stone (Author), Katie Horvath (Author), Michael J Miley (Author), Chris Luft (Author), Joseph M DeSimone (Author), Shaomin Tian (Author), Aravinda M de Silva (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies indicate that tetravalent DENV vaccines must induce...