Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype.

• Главные авторы: Stefan W Metz (Автор), Ashlie Thomas (Автор), Alex Brackbill (Автор), Yi Xianwen (Автор), Michele Stone (Автор), Katie Horvath (Автор), Michael J Miley (Автор), Chris Luft (Автор), Joseph M DeSimone (Автор), Shaomin Tian (Автор), Aravinda M de Silva (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2018-09-01T00:00:00Z.
• Предметы: article
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Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies indicate that tetravalent DENV vaccines must induce...