Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health

• Main Authors: Kristine Williams (Author), Germán D. Carrasquilla (Author), Lars Roed Ingerslev (Author), Mette Yde Hochreuter (Author), Svenja Hansson (Author), Nicolas J. Pillon (Author), Ida Donkin (Author), Soetkin Versteyhe (Author), Juleen R. Zierath (Author), Tuomas O. Kilpeläinen (Author), Romain Barrès (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contributes to the beneficial effects of exercise on hum...