A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

Our previous studies have shown that the introduction of structurally diverse benzyl side chains at the C5-NH2 position of oseltamivir to occupy 150-cavity contributes to the binding affinity with neuraminidase and anti-influenza activity. To obtain broad-spectrum neuraminidase inhibitors, we design...

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Main Authors: Jiwei Zhang (Author), Chuanfeng Liu (Author), Ruifang Jia (Author), Xujie Zhang (Author), Jian Zhang (Author), Chiara Bertagnin (Author), Anna Bonomini (Author), Laura Guizzo (Author), Yuanmin Jiang (Author), Huinan Jia (Author), Shuzhen Jia (Author), Xiuli Ma (Author), Arianna Loregian (Author), Bing Huang (Author), Peng Zhan (Author), Xinyong Liu (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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