Activation of NR1H3 attenuates the severity of septic myocardial injury by inhibiting NLRP3 inflammasome

• Main Authors: Chao Deng (Author), Qiong Liu (Author), Huadong Zhao (Author), Lu Qian (Author), Wangrui Lei (Author), Wenwen Yang (Author), Zhenxing Liang (Author), Ye Tian (Author), Shaofei Zhang (Author), Changyu Wang (Author), Ying Chen (Author), Yang Yang (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Most sepsis deaths are due to the development of multiple organ failure, in which heart failure is a recognized manifestation of sepsis. To date, the role of liver X receptors α (NR1H3) in sepsis is still uncertain. Here, we hypothesized that NR1H3 mediates multiple essential sepsis‐related...