Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway

• Main Authors: Yuhan Jiao (Author), Ming Xin (Author), Juanjuan Xu (Author), Xindong Xiang (Author), Xuan Li (Author), Jingjing Jiang (Author), Xiuqin Jia (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context Polyphyllin II (PPII) is a steroidal saponin isolated from Rhizoma Paridis. It exhibits significant antitumor activity such as anti-proliferation and pro-apoptosis in lung cancer.Objective To explore whether PPII induce autophagy and the relationship between autophagy and apoptosis in non-sm...