Combination of anti-CGRP/CGRP-R mAbs with onabotulinumtoxin A as a novel therapeutic approach for refractory chronic migraine: a retrospective study of real-world clinical evidence and a protocol for a double-blind, randomized clinical trial to establish the efficacy and safety

• Main Authors: M. T. Corasaniti (Author), G. W. Lawrence (Author), G. Bagetta (Author), R. Iannacchero (Author), A. Tarsitano (Author), A. Monteleone (Author), M. Pagliaro (Author), P. Tonin (Author), G. Sandrini (Author), P. Nicotera (Author), D. Scuteri (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic migraine is a disabling neurovascular disorder that ranks amongst the top causes of years lived with disability worldwide. The duration and the frequency of migraine affect cognitive and affective domains, inducing worsening of memory, executive functions, orientation and causing anxiety. Po...