Deciphering the multifaceted roles and clinical implications of 2-hydroxyglutarate in cancer

• Main Authors: Jie Hao (Author), Ziyi Huang (Author), Siyue Zhang (Author), Kefan Song (Author), Juncheng Wang (Author), Chao Gao (Author), Zhiqing Fang (Author), Ning Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increasing evidence indicates that 2-hydroxyglutarate (2HG) is an oncometabolite that drives tumour formation and progression. Due to mutations in isocitrate dehydrogenase (IDH) and the dysregulation of other enzymes, 2HG accumulates significantly in tumour cells. Due to its structural similarity to...