Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment.

• Main Authors: Vanessa Carregaro (Author), José M Ribeiro (Author), Jesus G Valenzuela (Author), Djalma L Souza-Júnior (Author), Diego L Costa (Author), Carlo J F Oliveira (Author), Laís A Sacramento (Author), Manuela S L Nascimento (Author), Cristiane M Milanezi (Author), Fernando Q Cunha (Author), João S Silva (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sand fly saliva plays a crucial role in establishing Leishmania infection. We identified adenosine (ADO) and adenosine monophosphate (AMP) as active pharmacologic compounds present in Phlebotomus papatasi saliva that inhibit dendritic cell (DC) functions through a PGE2/IL 10-dependent mechanism.Here...