A novel prostaglandin I2 agonist, ONO-1301, attenuates liver inflammation and suppresses fibrosis in non-alcoholic steatohepatitis model mice

• Main Authors: Satoko Motegi (Author), Atsunori Tsuchiya (Author), Takahiro Iwasawa (Author), Takeki Sato (Author), Masaru Kumagai (Author), Kazuki Natsui (Author), Shunsuke Nojiri (Author), Masahiro Ogawa (Author), Suguru Takeuchi (Author), Yosiki Sakai (Author), Shigeru Miyagawa (Author), Yoshiki Sawa (Author), Shuji Terai (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background ONO-1301 is a novel long-lasting prostaglandin (PG) I2 mimetic with inhibitory activity on thromboxane (TX) A2 synthase. This drug can also induce endogenous prostaglandin (PG)I2 and PGE2 levels. Furthermore, ONO-1301 acts as a cytokine inducer and can initiate tissue repair in a...