A Mixed Thermosensitive Hydrogel System for Sustained Delivery of Tacrolimus for Immunosuppressive Therapy

• Main Authors: Hsiu-Chao Lin (Author), Madonna Rica Anggelia (Author), Chih-Chi Cheng (Author), Kuan-Lin Ku (Author), Hui-Yun Cheng (Author), Chih-Jen Wen (Author), Aline Yen Ling Wang (Author), Cheng-Hung Lin (Author), I-Ming Chu (Author)
• Format: Book
• Published: MDPI AG, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tacrolimus is an immunosuppressive agent for acute rejection after allotransplantation. However, the low aqueous solubility of tacrolimus poses difficulties in formulating an injection dosage. Polypeptide thermosensitive hydrogels can maintain a sustained release depot to deliver tacrolimus. The cop...