Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults.

• Main Authors: María C Albareda (Author), Ana M De Rissio (Author), Gonzalo Tomas (Author), Alicia Serjan (Author), María G Alvarez (Author), Rodolfo Viotti (Author), Laura E Fichera (Author), Mónica I Esteva (Author), Daniel Potente (Author), Alejandro Armenti (Author), Rick L Tarleton (Author), Susana A Laucella (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Adults with chronic Trypanosoma cruzi exhibit a poorly functional T cell compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T cells and increased levels of terminally differentiated T cells. It is possible that persistent infection an...