Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays

Cystic fibrosis (CF) is a genetic disease affecting the lungs and pancreas and causing progressive damage. CF is caused by mutations abolishing the function of CFTR, a protein whose role is chloride's mobilization in the epithelial cells of various organs. Recently a therapy focused on small mo...

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Main Authors: Alice Parodi (Author), Giada Righetti (Author), Emanuela Pesce (Author), Annalisa Salis (Author), Valeria Tomati (Author), Cristina Pastorino (Author), Bruno Tasso (Author), Mirko Benvenuti (Author), Gianluca Damonte (Author), Nicoletta Pedemonte (Author), Elena Cichero (Author), Enrico Millo (Author)
Format: Book
Published: MDPI AG, 2022-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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