Design and Optimization of a Nanoparticulate Pore Former as a Multifunctional Coating Excipient for pH Transition-Independent Controlled Release of Weakly Basic Drugs for Oral Drug Delivery

• Main Authors: Hao Han R. Chang (Author), Kuan Chen (Author), Jamie Anne Lugtu-Pe (Author), Nour AL-Mousawi (Author), Xuning Zhang (Author), Daniel Bar-Shalom (Author), Anil Kane (Author), Xiao Yu Wu (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bioavailability of weakly basic drugs may be disrupted by dramatic pH changes or unexpected pH alterations in the gastrointestinal tract. Conventional organic acids or enteric coating polymers cannot address this problem adequately because they leach out or dissolve prematurely, especially during co...