Antiproliferative effects of sulphonamide carbonic anhydrase inhibitors C18, SLC-0111 and acetazolamide on bladder, glioblastoma and pancreatic cancer cell lines

• 主要な著者: Silvia Mussi (著者), Sara Rezzola (著者), Paola Chiodelli (著者), Alessio Nocentini (著者), Claudiu T. Supuran (著者), Roberto Ronca (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Carbonic anhydrase IX/XII (CA IX/XII), are cell-surface enzymes typically expressed by cancer cells as a form of adaptation to hypoxia and acidosis. It has been widely reported that these proteins play pivotal roles in cancer progression fostering cell migration, aggressiveness and resistance to fir...