An Advanced Automated Patch Clamp Protocol Design to Investigate Drug-Ion Channel Binding Dynamics

• Main Authors: Peter Lukacs (Author), Krisztina Pesti (Author), Mátyás C. Földi (Author), Katalin Zboray (Author), Adam V. Toth (Author), Gábor Papp (Author), Arpad Mike (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating. In this study, we aim to demonstrate that depth of analysis can be combined with acceptab...