Design of an Optimized Wilms' Tumor 1 (WT1) mRNA Construct for Enhanced WT1 Expression and Improved Immunogenicity In Vitro and In Vivo

• Main Authors: Daphné Benteyn (Author), Sébastien Anguille (Author), Sandra Van Lint (Author), Carlo Heirman (Author), An MT Van Nuffel (Author), Jurgen Corthals (Author), Sebastian Ochsenreither (Author), Wim Waelput (Author), Katrien Van Beneden (Author), Karine Breckpot (Author), Viggo Van Tendeloo (Author), Kris Thielemans (Author), Aude Bonehill (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor antigen-encoding mRNA for dendritic cell (DC)-based vaccination has gained increasing popularity in recent years. Within this context, two main strategies have entered the clinical trial stage: the use of mRNA for ex vivo antigen loading of DCs and the direct application of mRNA as a source of...