CLEC5a-directed bispecific antibody for effective cellular phagocytosis

• Main Authors: Vivekananda Kedage (Author), Diego Ellerman (Author), Mingjian Fei (Author), Wei-Ching Liang (Author), Gu Zhang (Author), Eric Cheng (Author), Juan Zhang (Author), Yongmei Chen (Author), Haochu Huang (Author), Wyne P. Lee (Author), Yan Wu (Author), Minhong Yan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB). Here, we describe a bispecific antibody approach that harnesses phag...