Towards SINEUP-based therapeutics: Design of an in vitro synthesized SINEUP RNA

• Main Authors: Paola Valentini (Author), Bianca Pierattini (Author), Elsa Zacco (Author), Damiano Mangoni (Author), Stefano Espinoza (Author), Natalie A. Webster (Author), Byron Andrews (Author), Piero Carninci (Author), Gian Gaetano Tartaglia (Author), Luca Pandolfini (Author), Stefano Gustincich (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SINEUPs are a novel class of natural and synthetic non-coding antisense RNA molecules able to increase the translation of a target mRNA. They present a modular organization comprising an unstructured antisense target-specific domain, which sets the specificity of each individual SINEUP, and a struct...