Physiologically based pharmacokinetic modeling of imatinib and N‐desmethyl imatinib for drug-drug interaction predictions

• Main Authors: Helena Leonie Hanae Loer (Author), Christina Kovar (Author), Simeon Rüdesheim (Author), Fatima Zahra Marok (Author), Laura Maria Fuhr (Author), Dominik Selzer (Author), Matthias Schwab (Author), Thorsten Lehr (Author)
• Format: Book
• Published: Wiley, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The first‐generation tyrosine kinase inhibitor imatinib has revolutionized the development of targeted cancer therapy and remains among the frontline treatments, for example, against chronic myeloid leukemia. As a substrate of cytochrome P450 (CYP) 2C8, CYP3A4, and various transporters, ima...