Physiologically based pharmacokinetic modeling of imatinib and N‐desmethyl imatinib for drug-drug interaction predictions

• मुख्य लेखकों: Helena Leonie Hanae Loer (लेखक), Christina Kovar (लेखक), Simeon Rüdesheim (लेखक), Fatima Zahra Marok (लेखक), Laura Maria Fuhr (लेखक), Dominik Selzer (लेखक), Matthias Schwab (लेखक), Thorsten Lehr (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2024-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract The first‐generation tyrosine kinase inhibitor imatinib has revolutionized the development of targeted cancer therapy and remains among the frontline treatments, for example, against chronic myeloid leukemia. As a substrate of cytochrome P450 (CYP) 2C8, CYP3A4, and various transporters, ima...