Oseltamivir Enhances Hippocampal Network Synchronization

• Main Authors: Atsushi Usami (Author), Takuya Sasaki (Author), Nobuhiro Satoh (Author), Takahiro Akiba (Author), Satoshi Yokoshima (Author), Tohru Fukuyama (Author), Kenzo Yamatsugu (Author), Motomu Kanai (Author), Masakatsu Shibasaki (Author), Norio Matsuki (Author), Yuji Ikegaya (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization b...