Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis

• Main Authors: Yihang Dai (Author), Zhixin Jia (Author), Cong Fang (Author), Meixia Zhu (Author), Xiaoning Yan (Author), Yinhuan Zhang (Author), Hao Wu (Author), Menghan Feng (Author), Lirong Liu (Author), Beibei Huang (Author), Yueting Li (Author), Jie Liu (Author), Hongbin Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To explore the possible mechanisms of cholestasis induced by Polygoni Multiflori Radix (PM).Methods: Low and high doses of water extract of PM were given to mice by gavage for 8 weeks. The serum biochemical indexes of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gluta...