Trimetazidine Attenuates Heart Failure by Improving Myocardial Metabolism via AMPK

• Main Authors: Hongyang Shu (Author), Weijian Hang (Author), Yizhong Peng (Author), Jiali Nie (Author), Lujin Wu (Author), Wenjun Zhang (Author), Dao Wen Wang (Author), Ning Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Energic deficiency of cardiomyocytes is a dominant cause of heart failure. An antianginal agent, trimetazidine improves the myocardial energetic supply. We presumed that trimetazidine protects the cardiomyocytes from the pressure overload-induced heart failure through improving the myocardial metabo...