TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy

• Main Authors: Caroline Sunggip (Author), Kakeru Shimoda (Author), Sayaka Oda (Author), Tomohiro Tanaka (Author), Kazuhiro Nishiyama (Author), Supachoke Mangmool (Author), Akiyuki Nishimura (Author), Takuro Numaga-Tomita (Author), Motohiro Nishida (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiac hypertrophy, induced by neurohumoral factors, including angiotensin II and endothelin-1, is a major predisposing factor for heart failure. These ligands can induce hypertrophic growth of neonatal rat cardiomyocytes (NRCMs) mainly through Ca2+-dependent calcineurin/nuclear factor of activated...