Discovery of orally active chalcones as histone lysine specific demethylase 1 inhibitors for the treatment of leukaemia

• Ngā kaituhi matua: Yang Li (Author), Ying Sun (Author), Yang Zhou (Author), Xinyang Li (Author), Huan Zhang (Author), Guojun Zhang (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Histone lysine specific demethylase 1 (LSD1) has emerged as an attractive molecule target for the discovery of potently anticancer drugs to treat leukaemia. In this study, a series of novel chalcone derivatives were designed, synthesised and evaluated for their inhibitory activities against LSD1 in ...