Differential effects of mitogen-activated protein kinase pathway inhibitors on P-glycoprotein activation

• Main Authors: Hirokazu Wakuda (Author), Shino Miyauchi (Author), Kana Maruyama (Author), Satomi Kagota (Author), Kazuki Nakamura (Author), Keizo Umegaki (Author), Shizuo Yamada (Author), Kazumasa Shinozuka (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to evaluate the effects of the mitogen-activated protein kinase (MAPK) pathway inhibitors SB203580, CMPD-1, SB239063, SP600125, and FR180204 on the activity of P-glycoprotein (P-gp) and to assess whether the MAPK pathway affects P-gp directly. Changes in the fluorescence of...