Profiling Differential Effects of 5 Selective Serotonin Reuptake Inhibitors on TLRs-Dependent and -Independent IL-6 Production in Immune Cells Identifies Fluoxetine as Preferred Anti-Inflammatory Drug Candidate

Profiling Differential Effects of 5 Selective Serotonin Reuptake Inhibitors on TLRs-Dependent and -Independent IL-6 Production in Immune Cells Identifies Fluoxetine as Preferred Anti-Inflammatory Drug Candidate

Excessive proinflammatory cytokine production induced by abnormal activation of Toll-like receptor (TLR) signaling, for example, by SARS-CoV-2 infection, can cause a fatal cytokine storm. The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine, used to treat depression, were r...

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Main Authors: Yohei Takenaka (Author), Ryu Tanaka (Author), Kazuki Kitabatake (Author), Kouji Kuramochi (Author), Shin Aoki (Author), Mitsutoshi Tsukimoto (Author)
Format: Book
Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
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3rd Floor Main Library

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