Relationship Between the Free and Total Methotrexate Plasma Concentration in Children and Application to Predict the Toxicity of HD-MTX

• Main Authors: Wei-Chong Dong (Author), Jia-Liang Guo (Author), Xi-Kun Wu (Author), Meng-Qiang Zhao (Author), Hao-Ran Li (Author), Zhi-Qing Zhang (Author), Ye Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-dose methotrexate (HD-MTX) can be highly effective as well as extremely toxic. Many drug molecules can bind to plasma proteins to different extents in vivo, whereas only the free drug can reach the site of action to exert a pharmacological effect and cause toxicity. However, free MTX concentrat...