In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis

• मुख्य लेखकों: Dahara Keyse Carvalho Silva (लेखक), Jessicada Silva Teixeira (लेखक), Diogo Rodrigo Magalhães Moreira (लेखक), Tiago Fernandes da Silva (लेखक), Eliezer Jesus de Lacerda Barreiro (लेखक), Humberto Fonseca de Freitas (लेखक), Samuel Silva da Rocha Pita (लेखक), André Lacerda Braga Teles (लेखक), Elisalva Teixeira Guimarães (लेखक), Milena Botelho Pereira Soares (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Leishmaniasis are group of neglected diseases with worldwide distribution that affect about 12 million people. The current treatment is limited and may cause severe adverse effects, and thus, the search for new drugs more effective and less toxic is relevant. We have previously investigated the immu...