Improved Syntheses of the mGlu5 Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling

Improved Syntheses of the mGlu5 Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling

The Sonogashira cross-coupling, a key step in the syntheses of the mGlu5 antagonists MMPEP and MTEP, provided an improved three-step method for the preparation of MMPEP in 62% overall yield. Using Spartan molecular modeling kit an explanation for the failure to employ analogues method in the synthes...

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Main Authors: Boshuai Mu (Author), Linjing Mu (Author), Roger Schibli (Author), Simon M. Ametamey (Author), Selena Milicevic Sephton (Author)
Format: Book
Published: MDPI AG, 2018-02-01T00:00:00Z.
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3rd Floor Main Library

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