Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways

• Автори: Anastasia S. Tsagkarakou (Автор), Styliani A. Chasapi (Автор), Symeon M. Koulas (Автор), Ioannis Tsialtas (Автор), Efthimios Kyriakis (Автор), Christina E. Drakou (Автор), Sándor Kun (Автор), László Somsák (Автор), Georgios A. Spyroulias (Автор), Anna-Maria G. Psarra (Автор), Demetres D. Leonidas (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2021-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The binding of p-coumaroyl glucose to glycogen phosphorylase (GP; a pharmaceutical target for the development of antihyperglycaemic drugs) has been studied by kinetics, and X-ray crystallography while its effect to HepG2 cells metabolism has been assessed by NMR metabolomics. p-Coumaroyl glucose is...