Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

• Principais autores: Atsuko Ohkubo (Autor), Tomomi Chida (Autor), Hidetomo Kikuchi (Autor), Tadashi Tsuda (Autor), Katsuyoshi Sunaga (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2017-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (NFP) and midazolam (MDZ), in male Wistar rats. Oral...