Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

Effects of tomato juice on the pharmacokinetics of CYP3A4-substrate drugs

We previously demonstrated that tomato juice (TJ) contains potent mechanism-based inhibitor(s) of CYP3A4. In this study, we investigated the effects of TJ and grapefruit juice (GFJ) on the pharmacokinetics of the CYP3A4-substrate drugs, nifedipine (NFP) and midazolam (MDZ), in male Wistar rats. Oral...

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Main Authors: Atsuko Ohkubo (Author), Tomomi Chida (Author), Hidetomo Kikuchi (Author), Tadashi Tsuda (Author), Katsuyoshi Sunaga (Author)
Format: Book
Published: Elsevier, 2017-09-01T00:00:00Z.
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