Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial

• Main Authors: Chi Zhang (Author), Daogang Guan (Author), Miao Jiang (Author), Chao Liang (Author), Li Li (Author), Ning Zhao (Author), Qinglin Zha (Author), Wandong Zhang (Author), Cheng Lu (Author), Ge Zhang (Author), Jian Liu (Author), Aiping Lu (Author)
• Format: Book
• Published: BMC, 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Leflunomide (LEF) is a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, there are still a few nonresponders. It is logical to suggest that employing combinations including LEF that produce synergistic effects in terms of pharmacologi...