Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Differentiated Intestinal Cells

• Main Authors: Elena Moroz (Author), Soo Hyeon Lee (Author), Ken Yamada (Author), François Halloy (Author), Saúl Martínez-Montero (Author), Hartmut Jahns (Author), Jonathan Hall (Author), Masad J Damha (Author), Bastien Castagner (Author), Jean-Christophe Leroux (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nucleic acid therapy can be beneficial for the local treatment of gastrointestinal diseases that currently lack appropriate treatments. Indeed, several oligonucleotides (ONs) are currently progressing through clinical trials as potential treatments for inflammatory bowel diseases. However, due to lo...